Organic Seminar - Shauna Paradine

The Organic Seminar Series presents: Shauna Paradine

University of Rochester

Host: Kami Hull

Title: Catalytic strategies for the selective construction of sp³-rich organic scaffolds

Location: WEL 2.122

Refreshments served at 3:15pm

The development of new methods for the construction of small molecule organic scaffolds is essential for the advancement of organic synthesis. Methods to construct more sp³-rich scaffolds tend to lack generality and versatility, limiting the inclusion of such scaffolds in compound libraries for drug discovery and other applications. By combining fundamental advances in transition metal catalysis with organic synthesis, we aim to discover new reactions to solve unmet challenges in the construction of functional sp³-rich organic scaffolds. In one area, we have found that identifying “unconventional” ligand platforms for palladium catalysis leads to new reactivity and selectivity in olefin heteroannulation reactions. In another area, we have found that copper complexes can promote a range of oxidative radical addition reactions.