A&P Seminar - Kallol Gupta

The Analytical and Physical Seminar Series presents: Kallol Gupta

Yale School of Medicine

Host: Jenny Brodbelt

Title: Nanoscale molecular cartography of the cellular membranes

Location: WEL 2.122

Refreshments served at 3:15pm

Macromolecular organization between proteins and lipids at the cellular membrane is fundamental to any membrane-associated cellular signaling events. Capturing these associations demands molecular resolution sufficient to unambiguously determine both the identities of large protein complexes and those of small bound lipids and ligands. Simultaneously, we need nanoscale spatial resolution to capture these assemblies directly from their endogenous membrane of action. Addressing these analytical challenges, we will present our ongoing work in the lab that combines native mass spectrometry with chemical biology, molecular imaging, and other orthogonal tools to render a quantitative molecular view of the protein-lipid organization in the membrane and how that drives downstream cellular siganling.