Michael Krische
- Professor
- Robert A. Welch Chair in Science
- Chemistry
Contact Information
Biography
Professor Michael J. Krische obtained a B.S. degree in Chemistry from the University of California at Berkeley (1989), where he performed research with Professor Henry Rapoport. After a year abroad as a Fulbright Fellow, he initiated doctoral studies at Stanford University with Professor Barry Trost as a Veatch Graduate Fellow. Following receipt of his Ph.D. degree (1996), he joined the laboratory of Professor Jean-Marie Lehn at the Université Louis Pasteur as an NIH Post-Doctoral Fellow. In 1999, he joined the faculty at the University of Texas at Austin. He was promoted directly to the rank of full professor (2004) and shortly thereafter appointed the Robert A. Welch Chair in Science (2007). Professor Krische has pioneered the use of hydrogenation and transfer hydrogenation in catalytic C-C bond formation, enabling a departure from the use of premetalated reagents in chemical synthesis.
Research
Professor Krische has pioneered the use of hydrogenation and transfer hydrogenation in catalytic C-C bond formation, enabling a departure from the use of premetalated reagents in chemical synthesis. Additionally, he has developed hydrogen auto-transfer reactions that affect direct stereo- and site-selective conversion of lower alcohols to higher alcohols. Training in Krische laboratory encompasses enantioselective catalysis, organometallic and synthetic chemistry, including natural product total synthesis.
Fields of Interest
- Organic Chemistry
Education
- B.S. Chemistry, Univ. of California at Berkeley
- Ph.D. Chemistry, Stanford University
- NIH Post-Doc., Université Louis Pasteur
Publications
“Aryl Halide Cross-Coupling via Formate-Mediated Transfer Hydrogenation,” Cho, Y.; Chang, Y.-H.; Quirion, K. P.; Strong, Z. H.; Dubey, Z. J.; Nguyen, N.; Lee, S.; Taylor, N. S.; Hoover, J. M.; White, N. A.; Liu, P.; Krische, M. J. Nat. Chem. 2025, 17, 710–718.
“Enantioselective N-Heteroaryl C-H Functionalization for Piperidine-Azine Conjugation: Alkynes as Allylmetal Pronucleophiles in Dearomative Addition-Hydrogen Auto-Transfer,” Lee, S.; Teoh, Y. S.; Xie, P.-P.; McManus, E. M.; Gonzalez, B. I.; Claggett, T. A.; Liu, P.; Krische, M. J. J. Am. Chem. Soc. 2025, 147, 41946–41955.
“Catalytic Enantioselective C-C Coupling of Alcohols for Polyketide Total Synthesis beyond Chiral Auxiliaries and Premetalated Reagents,” Wu, J.; Verboom, K. L.; Krische, M. J. Chem. Rev. 2024, 124, 13715–13735.
Awards
- Yamada-Koga Prize (2025)
- Palladium Global Science Award (2025)
- Israeli Chemical Society, Honorary Member (2022)
- ACS Award for Creative Work in Synthetic Organic Chemistry (2020)
- Korean Society of Organic Chemistry Lectureship Award (2019)
- Ta-Shue Chou Lectureship Award, Institute of Chemistry, Academia Sinica, Taiwan (2019)
- Fellow of the American Association for the Advancement of Science (AAAS) (2017)
- Royal Society of Chemistry, Pedler Award (2015)
- Eun Lee Lectureship Award, Korea (2015)
- Japanese Society for the Promotion of Science (JSPS) Research Fellowship (2013)
- Fellow of the Royal Society of Chemistry (2013)
- ACS Cope Scholar Award (2013)
- GlaxoSmithKline Scholar Award (2012)
- Mukaiyama Award, Society of Synthetic Organic Chemistry, Japan (SSOCJ), 2010
- Humboldt Foundation Senior Research Award (2009-2011)
- Freiburg Institute for Advanced Studies (FRIAS) External Senior Fellow, 1/09- 12/11
- Tetrahedron Young Investigator Award (2009)
- Novartis Lectureship Award (2008)
- Presidential Green Chemistry Challenge Award (2007)
- Dowpharma Prize - Creativity in Chiral Chemistry (2007)
- ACS Elias J. Corey Award (2007)
- Solvias Ligand Prize (2006)
- The Society of Synthetic Chemistry, Japan Lectureship on Organic Synthesis (2005)
- Johnson & Johnson Focused Giving Award (2005)
- Camille Dreyfus Teacher-Scholar Award (2003)
- Alfred P. Sloan Research Fellow (2003)
- Eli Lilly Granteeship for Untenured Faculty (2002)
- Frasch Foundation Award in Chemistry (2002)
- Research Corporation, Cottrell Scholar Award (2002)
- UT Austin, Teaching Excellence Award (2002)
- Thieme Chemistry Journal Award (2001)
- National Science Foundation, CAREER Award (2000)